A friend invites you to dinner. You are sitting in the living room with his wife and their two children and the family dog. Suddenly, without warning, you jump up, pull out your dick and fuck the dog in front of all of them. The children scream, the wife faints and the friend throws you out of the house. Do you think you will be invited back?

That's how the phase was explained to me. Kind of hard to forget, isn't it? "Screw the pooch" simply means a mistake that there is no coming back from. Losing the capsule was one of those mistakes